A woman is dead and four people are seriously injured after a head-on crash between two cars in the remote Goldfields region of WA on Sunday morning.   

Police say a Toyota Land Cruiser and a Nissan Navara were involved in the crash that occurred on the Great Central Road, 170 kilometres south-west of Warburton.   

The woman, believed to be in her 30s, was a passenger in the Nissan and died at the scene.

Police said the driver and three other passengers in the car had been seriously injured, while a fourth passenger “appears to have not been seriously injured”.

Police, St John Ambulance, and the Royal Flying Doctor Service (RFDS) were sent to the remote crash site after an emergency beacon was activated about 8am.  

Two RFDS aircraft were sent to the Kampa airstrip to transport the five patients.  

A third RFDS jet was on stand-by at Warburton to take one of the patients who is reported to have more serious injuries direct to Perth.

Police said the driver of the Land Cruiser did not appear to be seriously injured and was being taken to hospital by road.

Major Crash Investigation Section officers from Perth will travel to the scene to investigate the circumstances surrounding the crash.