The hosts got into the end zone on each of their opening two drives, with Herbert making an eight-yard touchdown pass to Oronde Gadsden II before Kimani Vidal, who finished with 117 rushing yards, punched in his first NFL touchdown from three yards.
Herbert then launched a 27-yard pass to the corner for Ladd McConkey to help make it 21-3 at half-time, but the Chargers quarterback gave up his only interception midway through the third quarter.
The Vikings took advantage, with Carson Wentz finding Jordan Addison at the back of the end zone to make it 24-10, but the hosts emphasised their dominance with a Tre’ Harris touchdown and two field goals in the fourth quarter.
The Vikings are now 3-4 and Wentz struggled on his fifth start in place of the injured JJ McCarthy, throwing for 144 yards, one touchdown and one interception while being sacked five times.
McCarthy has been out with a high ankle sprain suffered in week two but head coach Kevin O’Connell hopes the second-year quarterback can return next week, when the Vikings face a tough game at divisional rivals the Detroit Lions.
“If JJ is healthy, JJ will play,” said O’Connell. “I believe we’re right around the corner from seeing him be healthy, have a week of preparation and go compete.”